When was crystallization discovered

The method chosen must be selected based on the properties of the material being crystallized. Crystallization processes are often difficult to control, but sonocrystallization is a more modern method of crystallization that offers significant advantages over traditional methods.

Ultrasound radiation is known to induce acoustic cavitation in liquids through the formation, growth, and collapse of bubbles. The collapse of the bubble provides energy to encourage the nucleation process at the earliest possible point in time.

This results in highly repeatable and predictable crystallizations, and offer various benefits, including;. Discover the Sonocrystallization application page for more information.

Having decided on a method of crystallization, it is important to measure the progress and subsequent success of your crystallization process. Turbidity probes have been used to monitor crystallizations for decades, due to their ease of use, sensitivity, and affordability. Turbidity probes work by measuring light that is scattered by suspended solids in a liquid.

As an example, turbidity information for the crystallization and dissolution of adipic acid is shown below:. FBRM probes work by directing a laser beam down the probe, through rotating optics and focussing it at the probe window and measuring the light backscattered by particles in solution.

As the focussed beam scans the solution, individual particles can backscatter the light to the detector. Video imaging probes have also been used determine crystal shape and crystal size distribution, however, at present, they are hard to implement at a commercial scale due to operating temperature limits and the bulky size of such probes. Attenuated total reflectance Fourier transform infrared ATR-FTIR has also been used to gather solubility and supersaturation data, by measuring the concentration of solute in the mother liquor.

Additional information can also be gleaned, such as confirmation of the presence of additives or impurities. Chemists have a range of tools available to them for performing, monitoring, and controlling crystallization chemistry.

Syrris systems offer a range of solutions to the problem of crystallization monitoring and control. Atlas HD Crystallization is an intelligent and automated jacketed reactor system that offers a turbidity probe for monitoring the crystallization process, and the innovative SonoLab module to perform sonocrystallization or sonomilling techniques. Using the Syrris Atlas HD Crystallization system for your crystallization studies offers various benefits, including;.

Syrris products offer a range of solutions to the problem of crystallization control and monitoring. For more information about crystallization or how you can achieve better results using Syrris products, please contact us. What is crystallization? How does the crystallization process occur? The crystallization process consists of two major events: Nucleation — Molecules gather together in clusters in a defined manner. Crystals and Crystal Growth.

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