Where is the nicotinic acetylcholine receptor located

On This Page. Learning Objectives. Upon completion of this section, you will be able to: Describe the key function of nicotinic receptors. Describe where nicotinic receptors are found. Identify the key physiological effects that result from stimulation of nicotinic receptors by excessive amounts of acetylcholine. Key Function of Nicotinic Receptors.

Physiology of nicotinic receptors The nicotinic receptors are cylindrically-shaped proteins imbedded in synaptic walls that act as chemically-controlled sodium channels also called ligand-gated sodium channels that penetrate through the cell walls of post-synaptic nerves and myocytes at the skeletal neuromuscular junctions. Guyton and Hall The channel opening in the nicotinic receptor normally lasts less than a millisecond because the enzyme, cholinesterase, rapidly breaks down acetylcholine.

Guyton and Hall Toxic levels of cholinesterase inhibitors prevent the breakdown of acetylcholine. Taylor Clinical Picture Due to Nicotinic Effects of Cholinesterase Inhibitors These events help to explain why the initial phase of toxicity is manifested by over-stimulation characterized by myoclonic jerks, fasciculations and muscle spasms followed by weakness progressing to paralysis.

Locations of Nicotinic Receptors. Nicotinic receptors are located in the See also Figure 6 Skeletal neuromuscular junctions. Sympathetic and parasympathetic nervous system. Autonomic ganglia. Central nervous system. Clinical findings are related to effects on the: Neuromuscular junctions of skeletal muscles. Fasciculations and myotonic jerks, followed by weakness and paralysis. Sympathetic nervous system due to ganglionic stimulation of the adrenal gland.

EMBO J. Brams, M. A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors. PLoS Biol. Brejc, K. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature , — Buisson, B. Nicotine addiction: the possible role of functional upregulation.

Trends Pharmacol. Celie, P. Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron 41, — Cembella, A.

Spirolide composition of micro-extracted pooled cells isolated from natural plankton assemblages and from cultures of the dinoflagellate Alexandrium ostenfeldii. Toxins 7, — Chang, C. Isolation of neurotoxins from the venom of Bungarus multicintus and their modes of neuromuscular blocking action.

Google Scholar. Chiappinelli, V. K-bungarotoxin: a probe for the neuronal nicotinic receptor in the avian ciliary ganglion. Brain Res. Colombo, S. Biogenesis, trafficking and up-regulation of nicotinic ACh receptors. Conti-Fine, B. Myasthenia gravis: past, present, and future.

Corfield, P. The crystal structure of erabutoxin a at 2. Craig, A. Post-translationally modified neuropeptides from Conus venoms.

Daly, J. Nicotinic agonists, antagonists, and modulators from natural sources. Dani, J. Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. De Biasi, M. Reward, addiction, withdrawal to nicotine. Dellisanti, C. Dutertre, S. Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms. Neuropharmacology , — Ellison, M. Biochemistry 45, — Engel, A. Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment.

Lancet Neurol. Fainzilber, M. Biochemistry 33, — Folkers, K. Isolation of Erythrodine, an alkaloid of curare action, from Erythrina americana mill. Freedman, R. Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Psychiatry 38, 22— Fruchart-Gaillard, C. Fry, B. Early evolution of the venom system in lizards and snakes.

Giniatullin, R. Desensitization of nicotinic ACh receptors: shaping cholinergic signaling. Trends Neurosci. Gotti, C. Neuronal nicotinic receptors: from structure to pathology. Green, B.

Plant toxins that affect nicotinic acetylcholine receptors: a review. Grudzinska, J. Neuron 45, — Hansen, S. Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein.

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica. Harvey, S. Hauser, T. Comparison of acetylcholine receptor interactions of the marine toxins, desmethylspirolide C and gymnodimine. Neuropharmacology 62, — Haywood, A. Comparative morphology and molecular phylogenetic analysis of three new species of the genus Karenia dinophycea from New Zealand.

Hellyer, S. In vitro labelling of muscle type nicotinic receptors using a fluorophore-conjugated pinnatoxin F derivative. Toxicon 87, 17— Hogg, R. Nicotinic acetylcholine receptors as drug targets. Targets CNS Neurol. Nicotinic acetylcholine receptors: from structure to brain function.

Hone, A. Nicotinic acetylcholine receptors in neuropathic and inflammatory pain. FEBS Lett. J Biol. Hope, A. Hu, S. The 1. Structure 4, — Hu, T. Characterization of spirolides A, C, and desmethyl C, new marine toxins isolated from toxic plankton and contaminated shellfish. Huang, S. Hurst, R.

Nicotinic acetylcholine receptors: From basic science to therapeutics. Hussain, G. Role of plant derived alkaloids and their mechanism in neurodegenerative disorders.

Inserra, M. Iturriaga-Vasquez, P. Janes, R. Jennings, K. Methyllycaconitine, a naturally occurring insecticide with a high affinity for the insect cholinergic receptor. Experientia 42, — Jensen, A. Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.

Jepsen, T. ACS Med. Clozapine and agranulocytosis. Lancet [Letter] : Differential expression of D1 and D2 dopamine and m4 muscarinic acetylcholine receptor proteins in identified striatonigral neurons.

Synapse 27 : — Preliminary observations of oral nicotine therapy for inflammatory bowel disease: an open-label phase I—II study of tolerance.

Inflamm Bowel Dis 11 : — Ascending neural pathways in the isolated guinea-pig ileum: effect of muscarinic M1, M2 and M3 cholinergic antagonists. Neuroscience 91 : — Mol Pharmacol 78 : — Antagonistic effects of physostigmine and methylphenidate in man.

The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 20 : — A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. J Neurosci 30 : — Ji D, Dani JA Inhibition and disinhibition of pyramidal neurons by activation of nicotinic receptors on hippocampal interneurons.

J Neurophysiol 83 : — Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity. Neuron 31 : — Nat Neurosci 13 : — Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

J Neurosci 28 : — Pharmacologic interactions between the muscarinic cholinergic and dopaminergic systems in the modulation of prepulse inhibition in rats. Effects of transdermal nicotine on episodic memory in non-smokers with and without schizophrenia. Psychopharmacology : 89— Enlargement of cerebral third ventricle in psychotic patients with delayed response to neuroleptics.

Biol Psychiatry 27 : — Choline acetyltransferase in schizophrenia. Am J Psychiatry 50 : — Decreased mesopontine choline acetyltransferase levels in schizophrenia. Correlations with cognitive functions. Mol Chem Neuropathol 29 : — Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind week comparison. Kenakin T Functional selectivity in GPCR modulator screening. Comb Chem High Throughput Screen 11 : — The enhancement of contextual fear conditioning by ABT Behav Pharmacol 21 : — Choline acetyltransferase-containing neurons in rodent brain demonstrated by immunohistochemistry.

Physostigmine and cognition in schizotypal personality disorder. Schizophr Res 48 : 1—5. J Neural Transm : — Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS in healthy, male volunteers.

Klein C, Andersen B On the influence of smoking upon smooth pursuit eye movements of schizophrenics and normal controls. J Psychophysiology 5 : — Augmented prefrontal acetylcholine release during challenged attentional performance. Cereb Cortex 16 : 9— Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia. Arch Gen Psychiatry 59 : — Kuehn BM FDA warns of adverse events linked to smoking cessation drug and antiepileptics.

JAMA : — The partial alpha7 nicotine acetylcholine receptor agonist S enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 54 : — Br J Pharmacol 54 : — Probing the molecular mechanism of interaction between 4- n -butyl[4- 2-methylphenyl oxobutyl]-piperidine AC and the muscarinic M1 receptor: direct pharmacological evidence that AC is an allosteric agonist.

Mol Pharmacol 69 : — Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. J Pharmacol Exp Ther 65 : — Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties. Neuropsychopharmacology 35 : — Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system.

ACS Chem Neurosci 1 : — Nicotinic receptors, smoking and schizophrenia. Restor Neurol Neurosci 12 : — Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia.

Early-onset hypothesis of antipsychotic drug action: a hypothesis tested, confirmed and extended. Biol Psychiatry 57 : — Localization of muscarinic m3 receptor protein and M3 receptor binding in rat brain. Neuroscience 63 : — A light and electron microscopic study of m2 muscarinic acetylcholine receptor in the basal forebrain of the rat. J Comp Neurol : — Expression of ml-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation.

J Neurosci 15 : — Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 11 : — Levin ED Nicotinic systems and cognitive function. Nicotinic receptor subtypes and cognitive function. J Neurobiol 53 : — AR-R, and alpha7 nicotinic agonist, improves learning and memory in rats.

Behave Pharmacol 10 : — Persistence of chronic nicotine-induced cognitive facilitation. Behav Neural Biol 58 : — Chronic nicotinic agonist and antagonist effects on T-maze alternation. Physiol Behav 61 : — Transdermal nicotine effects on attention. Psychopharmacology Berl : — Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization.

Lewis DA, Moghaddam B Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations. Arch Neurol 63 : — Presynaptic nicotinic receptors facilitate monoaminergic transmission. Neurosci 18 : — AC 4-[3- 4-butylpiperidinyl -propyl]fluoro-4H-benzo[1,4]oxazinone , a selective muscarinic M1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus.

Molecular cloning and expression of a fifth muscarinic acetylcholine receptor. J Biol Chem : — Association of muscarinic m1 receptor genetic polymorphisms with psychiatric symptoms and cognitive function in schizophrenic patients. Neuropsychobiology 48 : 72— Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine vs haloperidol.

Structure-activity studies on 2-methyl 2 S -pyrrolidinylmethoxy pyridine ABT : an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. J Med Chem 40 : — Lohr JB, Flynn K Smoking and schizophrenia. Schizophr Res 8 : 93— Alpha-conotoxin AuIB selectively blocks alpha3 beta4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release. J Neurosci 18 : — Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.

Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station. Assay Drug Dev Technol 7 : — Reduced expression of the muscarinic 1 receptor cortical subtype in schizophrenia.

Novel modulatory mechanisms revealed by the sustained application of nicotine in the guinea-pig hippocampus in vitro. J Physiol : — Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas.

Neuron 33 : — Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron 27 : — Activation of the genetically defined m1 muscarinic receptor potentiates N -methyl- D -aspartate NMDA receptor currents in hippocampal pyramidal cells.

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Mol Pharmacol 75 : — Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia. Biol Psychiatry 54 : — Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature : — Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia.

J Chem Neuroanat 22 : — Differential effects of physostigmine and pilocarpine on the spatial memory deficits produced by two septo-hippocampal deafferentations in rats. Brain Res : — Heterogeneity of schizophrenia: relationship to latency of neuroleptic response. Psychiatry Res 37 : 97— Possible changes in striatal and limbic cholinergic systems in schizophrenia. Arch Gen Psychiatry 34 : — Nicotinic receptor activation excites distinct subtypes of interneurons in the rat hippocampus.

J Neurosci 19 : — Central cholinergic pathways in the rat: an overview based on an alternative nomenclature Ch1—Ch6. Neuroscience 10 : — Differential regulation of alpha7 nicotinic receptor gene CHRNA7 expression in schizophrenic smokers. J Mol Neurosci 40 : — Differential coupling of m2 and m4 muscarinic receptors to inhibition of adenylyl cyclase by Gi alpha and G o alpha subunits.

Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.

Mol Pharmacol 70 : — Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

Moran PM Differential effects of scopolamine and mecamylamine on working and reference memory in the rat. Pharmacol Biochem Behav 45 : — Mol Pharmacol 57 : — Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo-interpeduncular system. J Med Chem 43 : — A comparative study on the effects of nicotine and GTS, a new nicotinic agonist, on the locomotor activity and brain monoamine level.

Jpn J Pharmacol 78 : — Evaluation of N -desmethylclozapine as a potential antipsychotic—preclinical studies. Neuropsychopharmacology 32 : — Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.

Acute nicotinic blockade produces cognitive impairment in normal humans. Age-related effects of the nicotinic antagonist mecamylamine on cognition and behavior. Neuropsychopharmacology 10 : 93— Effects of nicotinic stimulation on cognitive performance. Curr Opin Pharmacol 4 : 36— Identification of separable cognitive factors in schizophrenia.

Schizophr Res 72 : 29— Brain-selective stimulation of nicotinic receptors by TC enhances ACh transmission from frontoparietal cortex and memory in rodents. Prog Neuropsychopharmacol Biol Psychiatry 26 : — Proof-of-concept trial of an alpha nicotinic agonist in schizophrenia. Arch Gen Psychiatry 63 : — Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents.

Transdermal scopolamine psychosis. JAMA : Neuronal nicotinic alpha 7 receptor expressed in Xenopus oocytes presents five putative binding sites for methyllycaconitine. Weight effects associated with antipsychotics: a comprehensive database analysis. Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice.

Learn Membr 5 : — Pazzagli A, Pepeu G Amnesic properties of scopolamine and brain acetylcholine in the rat. Int J Neuropharmacol 4 : — Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography.

J Neurochem 82 : — The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex. Biol Psychiatry 49 : — The inhibition of the conditioned response and the counteraction of schizophrenia by muscarinic stimulation of the brain.

Ann NY Acad Sci 66 : — Immunocytochemical localization of choline acetyltransferase within the rat neostriatum: a correlated light and electron microscopic study of cholinergic neurons and synapses. Prog Neurobiol 84 : — SSR, a novel selective alpha7 nicotinic receptor partial agonist: II efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32 : 17— Postmortem studies in schizophrenia. Schizophr Bull 24 : — Psychopharmacology : 50— Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT Muscarinic and nicotinic modulation of cortical acetylcholine release monitored by in vivo microdialysis in freely moving adult rats.

Synapse 17 : 92— Correlation of prepulse inhibition and Wisconsin Card Sorting Test in schizophrenia and controls: effects of smoking status. Schizophr Res : 91— Treating the cognitive deficits of schizophrenia with alpha4beta2 neuronal nicotinic receptor agonists. Curr Pharm Des 16 : — In vivo determination of muscarinic acetylcholine receptor availability in schizophrenia.

Early onset of treatment effects with oral risperidone. BMC Psychiatry 7 : 4. Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice. Eur J Pharmacol : 58— Prog Neuropsychopharmacol Biol Psychiatry 33 : — Cognitive effects of nicotine.

Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. Pharmacological characteristics of facilitation of hippocampal population spikes by cholinomimetics.

Neuroscience 7 : — Localization of M 2 muscarinic acetylcholine receptor protein in cholinergic and non-cholinergic terminals in rat hippocampus. Neurosci Lett : — Neuroscience 86 : — Muscarinic receptor subtypes involved in hippocampal circuits. Comparison of the effects of four cholinomimetic agents on cognition in primates following disruption by scopolamine or by lists of objects. Evidence for elevated nicotine-induced structural plasticity in nucleus accumbens of adolescent rats.

McKee, S. Varenicline reduces alcohol self-administration in heavy-drinking smokers. Psychiatry 66, — Mereu, G. Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine. Meyer, E. Miller, D. Lobeline attenuates locomotor stimulation induced by repeated nicotine administration in rats. Once weekly administration of nicotine produces long-lasting locomotor sensitization in rats via a nicotinic receptor-mediated mechanism.

Mokdad, A. Actual causes of death in the United States, JAMA , — Morrison, C. The occurrence of tolerance to a central depressant effect of nicotine. Muller, J. Cholinergic innervation of pyramidal cells and parvalbumin-immunoreactive interneurons in the rat basolateral amygdala. Myers-Schulz, B. Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders. Nakauchi, S. Nashmi, R. Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons.

CNS localization of neuronal nicotinic receptors. Nestby, P. Ethanol, like psychostimulants and morphine, causes long-lasting hyperreactivity of dopamine and acetylcholine neurons of rat nucleus accumbens: possible role in behavioural sensitization. Nguyen, H. Subtype-selective up-regulation by chronic nicotine of high-affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography. Nisell, M.

Condition-independent sensitization of locomotor stimulation and mesocortical dopamine release following chronic nicotine treatment in the rat. Synapse 22, — Infusion of nicotine in the ventral tegmental area or the nucleus accumbens of the rat differentially affects accumbal dopamine release.

Ohno, M. Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats. Otani, S. Prefrontal cortex function, quasi-physiological stimuli, and synaptic plasticity. Paris 97, — Dopamine facilitates long-term depression of glutamatergic transmission in rat prefrontal cortex.

Neuroscience 85, — Dopaminergic modulation of long-term synaptic plasticity in rat prefrontal neurons. Cortex 13, — Pakhotin, P. Cholinergic interneurons control the excitatory input to the striatum.

Panagis, G. Nicotine injections into the ventral tegmental area increase locomotion and Fos-like immunoreactivity in the nucleus accumbens of the rat. Parker, S. Up-regulation of brain nicotinic acetylcholine receptors in the rat during long-term self-administration of nicotine: disproportionate increase of the alpha6 subunit.

Pascual, M. Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat. Paterson, D. Neuronal nicotinic receptors in the human brain. Peng, X. Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover. Perry, D. Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies.

Chronic nicotine differentially regulates alpha6- and beta3-containing nicotinic cholinergic receptors in rat brain. Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography.

Philibin, S. Striatal signal transduction and drug addiction. Picciotto, M. Nicotinic receptors in aging and dementia. Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine.

Pidoplichko, V. Nicotine activates and desensitizes midbrain dopamine neurons. Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction. Pons, S. Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration. Pontieri, F. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs.

Quick, M. Desensitization of neuronal nicotinic receptors. Radcliffe, K. Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission. Nicotinic modulation of glutamate and GABA synaptic transmission of hippocampal neurons. Reavill, C. Locomotor activity in rats after administration of nicotinic agonists intracerebrally. Reperant, C. Neuropharmacology 58, — Rezvani, A.

Cognitive effects of nicotine. Psychiatry 49, — Rice, M. Nicotine amplifies reward-related dopamine signals in striatum. Saal, D. Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons.

Neuron 37, — Sah, P. The amygdaloid complex: anatomy and physiology. Saito, M. Nicotine-induced sensitization in mice: changes in locomotor activity and mesencephalic gene expression. Salminen, O. Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.

Santos, G. Amphetamine- and nicotine-induced cross-sensitization in adolescent rats persists until adulthood. Schilstrom, B. Synapse 38, — Schwartz, R. Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo.

Sesack, S. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. Sharma, G. Modulation of presynaptic store calcium induces release of glutamate and postsynaptic firing. Neuron 38, — Shim, I. Nicotine-induced behavioral sensitization is associated with extracellular dopamine release and expression of c-Fos in the striatum and nucleus accumbens of the rat.

Simpson, J. Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxiety. Smith, B. Exposure to nicotine enhances acquisition of ethanol drinking by laboratory rats in a limited access paradigm. Socci, D. Nicotine enhances Morris water maze performance of young and aged rats. Aging 16, — Srinivasan, R. Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. Steensland, P. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking.

Steketee, J. Drug wanting: behavioral sensitization and relapse to drug-seeking behavior. Stuber, G. Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Takeuchi, Y. Reciprocal connections between the amygdala and parabrachial nuclei: ultrastructural demonstration by degeneration and axonal transport of horseradish peroxidase in the cat.

Tang, J. Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine. Neuron 63, — Tapper, A. Tepper, J. Feedforward and feedback inhibition in neostriatal GABAergic spiny neurons.

Theile, J. Ethanol enhances GABAergic transmission onto dopamine neurons in the ventral tegmental area of the rat. Tizabi, Y. Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shell. Tuomainen, P. Extracellular levels of dopamine in the nucleus accumbens in AA and ANA rats after reverse microdialysis of ethanol into the nucleus accumbens or ventral tegmental area.

Alcohol 29, — Tzschentke, T. Pharmacology and behavioral pharmacology of the mesocortical dopamine system. Vanderschuren, L. Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Vengeliene, V. Neuropharmacology of alcohol addiction. Vezina, P. Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs.

Sensitization, drug addiction and psychopathology in animals and humans. Psychiatry 31, — Vizi, E. Modulatory role of presynaptic nicotinic receptors in synaptic and non-synaptic chemical communication in the central nervous system.

Volkow, N. Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. Walters, C. The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice. Wang, F. Chronic nicotine treatment up-regulates human alpha3 beta2 but not alpha3 beta4 acetylcholine receptors stably transfected in human embryonic kidney cells. Watson, W. Prolonged effects of chronic ethanol treatment on responses to repeated nicotine administration: interactions with environmental cues.

Neuropharmacology 38, — Welsby, P. Nicotinic receptor-mediated enhancement of long-term potentiation involves activation of metabotropic glutamate receptors and ryanodine-sensitive calcium stores in the dentate gyrus. Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus. Whiteaker, P. Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.

Wilson, C. GABAergic inhibition in the neostriatum. Wooltorton, J. Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas. Xiao, C. Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area. Neuropsychopharmacology 34, — Yamazaki, Y. Nicotine-induced switch in the nicotinic cholinergic mechanisms of facilitation of long-term potentiation induction.

Yang, K. Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons. Yoshida, K. The effect of chronic ethanol administration on high affinity3H-nicotinic binding in rat brain. Naunyn Schmiedebergs Arch. Yu, D.